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DI-1859

CAT: 0931-T63930-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63930-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2247061-09-0
Target
Others, E1/E2/E3 Enzyme
Related Pathways
Ubiquitination, Others
Bioactivity
DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver injury.
Smiles
CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)C(=C)CN(C)C)C1CCCCC1
Molecular Formula
C30H45N5O3S
Molecular Weight
555.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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