DI-1859

• Target:

  Others|||E1/E2/E3 Enzyme

• Related Pathways:

  Ubiquitination|||Others

• Bioactivity:

  DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver injury.

• Smiles:

  CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)C(=C)CN(C)C)C1CCCCC1

• Molecular Formula:

  C30H45N5O3S

• Molecular Weight:

  555.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2247061-09-0