DI-87

• Target:

  Others|||DNA/RNA Synthesis

• Related Pathways:

  DNA Damage/DNA Repair|||Others|||Cell Cycle/Checkpoint

• Purity:

  0.9976

• Bioactivity:

  DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding. DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, which reduces the production of dNTP and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.

• Smiles:

  [C@@H] (SC=1N=C (N) C=C (N) N1) (C) C=2N=C (SC2C) C3=CC (OCCN4CCOCC4) =C (OC) C=C3

• Molecular Formula:

  C23H30N6O3S2

• Molecular Weight:

  502.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2107280-55-5