DI-87

• CAS Number :

  2107280-55-5

• Target :

  Others|||DNA/RNA Synthesis

• Related Pathways :

  DNA Damage/DNA Repair|||Others|||Cell Cycle/Checkpoint

• Purity :

  0.9976

• Bioactivity :

  DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding. DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, which reduces the production of dNTP and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.

• Smiles :

  [C@@H](SC=1N=C(N)C=C(N)N1)(C)C=2N=C(SC2C)C3=CC(OCCN4CCOCC4)=C(OC)C=C3

• Molecular Formula :

  C23H30N6O3S2

• Molecular Weight :

  502.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C