DI-87

CAT: 0931-T39550-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T39550-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2107280-55-5
Target
Others|||DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Others|||Cell Cycle/Checkpoint
Purity
0.9976
Bioactivity
DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding. DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, which reduces the production of dNTP and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.
Smiles
[C@@H](SC=1N=C(N)C=C(N)N1)(C)C=2N=C(SC2C)C3=CC(OCCN4CCOCC4)=C(OC)C=C3
Molecular Formula
C23H30N6O3S2
Molecular Weight
502.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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