EGFR-IN-59

CAT: 0931-T63556-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T63556-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2529891-44-7

Target

Others, Apoptosis, EGFR

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, JAK/STAT signaling, Others

Bioactivity

EGFR-IN-59 is an EGFR inhibitor with an IC50 value of 190 nM and an all-time apoptosis inducer. EGFR-IN-59 exhibited cytotoxicity against a non-small lung cancer cell line (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 μM, respectively. EGFR-IN-59 EGFR-IN-59 can be used to study a variety of cancers including non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.

Smiles

N(C=1C2=C(N=C(/C=C/C3=CC=C(OC)C=C3)N1)C=CC=C2)C4=CC=C(S(NC=5C=C(C)ON5)(=O)=O)C=C4

Molecular Formula

C27H23N5O4S

Molecular Weight

513.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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C8546-50	EGFR-IN-59
BA2304-10	XP-59
BA2825-1	TL02-59
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HY-157482	EBP-59
HY-174149	HDAC6-IN-59
ARC0735	PK-59
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GTR19273386-01	Tubulin-IN-59
GTR19236641	UT-59

EGFR-IN-59

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