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MET kinase-IN-3

CAT: 0931-T63309-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63309-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1446324-02-2
Target
C-Met/HGFR, VEGFR, Others
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others
Bioactivity
MET kinase-IN-3 is a potent, orally active MET inhibitor (IC50: 9.8 nM) that exhibits good broad-spectrum anti-proliferative effects on cancer cells.
Smiles
N(C1=C2C(NC=C(C2=O)C3=CC=C(F)C=C3)=CC=N1)C4=CC(F)=C(OC=5C(Cl)=C(N)N=CC5)C=C4
Molecular Formula
C25H16ClF2N5O2
Molecular Weight
491.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

MET kinase-IN-3
CAS Number1446324-02-2
PubChem CID71622198
IUPAC Name5-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluoroanilino]-3-(4-fluorophenyl)-1H-1,6-naphthyridin-4-one
Molecular FormulaC25H16ClF2N5O2
Molecular Weight491.9
XLogP5.5
Topological Polar Surface Area102
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity783
SMILES
C1=CC(=CC=C1C2=CNC3=C(C2=O)C(=NC=C3)NC4=CC(=C(C=C4)OC5=C(C(=NC=C5)N)Cl)F)F
InChI
InChI=1S/C25H16ClF2N5O2/c26-22-20(8-10-30-24(22)29)35-19-6-5-15(11-17(19)28)33-25-21-18(7-9-31-25)32-12-16(23(21)34)13-1-3-14(27)4-2-13/h1-12H,(H2,29,30)(H,31,33)(H,32,34)
InChIKey
VFFLZADJYBSNMH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MET kinase-IN-3
CAS: 1446324-02-2
CID: 71622198
Formula: C25H16ClF2N5O2
MW: 491.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight491.9
XLogP35.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass491.0960588
Monoisotopic Mass491.0960588
Topological Polar Surface Area102 Ų
Heavy Atom Count35
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T8795-01Met-kinase-in-2
T72777-01C-Met/HDAC-IN-3
T205572-01PROTAC c-Met degrader-3
T72407-01C-Met/MEK1/Flt-3-IN-1
T5055-01For-Met-OH
TP3134-01Met-12
T89523-01MET-IN-1
T211165-01MET Transcription-IN-1
T209390-01C-Met-IN-23
T63885-01C-Met-IN-13

Alternative Products

CatalogName
222956-01GLK (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, Germinal center Kinase Related Protein Kinase, MEKKK 3, MAP4K3) discontinued
406686-01MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, Germinal Center Kinase-Related Protein Kinase, GLK, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3, RAB8IPL1)
129569MEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3)
323550-01MAP3K3 (MAPKKK3, MEKK3, Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3)
317268-01GLK, NT (MAP4K3, RAB8IPL1, Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Germinal Center Kinase-related Protein Kinase, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3)
224106-01MEK Kinase (Mitogen-Activated Protein Kinase Kinase Kinase 3, MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3) discontinued
G3025-90CGLK, CT (Germinal Center Kinase Related Protein Kinase, Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, MAP4K3, MAPKKKK3, MAPK/ERK Kinase Kinase Kinase 3, MEK Kinase Kinase 3, MEKKK 3, RAB8IPL1)
129571-FITCMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (FITC)
129571-PEMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (PE)
129571-BiotinMEKK3 (MAPK/ERK Kinase Kinase 3, MEK Kinase 3, MEKK 3, Mitogen-activated Protein Kinase Kinase Kinase 3, MAP3K3, MAPKKK3) (Biotin)

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