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Met-kinase-in-2

CAT: 0931-T8795-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T8795-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2101241-90-9
Target
C-Met/HGFR, Others
Related Pathways
Others, Tyrosine Kinase/Adaptors
Bioactivity
MET kinase-IN-2, a selective and potent MET kinase inhibitor, demonstrates oral bioavailability and exhibits an IC50 value of 7.4 nM. It also possesses antitumor activity[1].
Smiles
CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2c1
Molecular Formula
C33H27FN4O4
Molecular Weight
562.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

MET kinase-IN-2
CAS Number2101241-90-9
PubChem CID134401435
IUPAC Name5-[3-fluoro-4-[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxyanilino]-3-phenyl-1H-1,6-naphthyridin-4-one
Molecular FormulaC33H27FN4O4
Molecular Weight562.6
XLogP6.4
Topological Polar Surface Area106
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Heavy Atom Count42
Formal Charge0
Complexity958
SMILES
CC(C)(COC1=CC2=NC=CC(=C2C=C1)OC3=C(C=C(C=C3)NC4=NC=CC5=C4C(=O)C(=CN5)C6=CC=CC=C6)F)O
InChI
InChI=1S/C33H27FN4O4/c1-33(2,40)19-41-22-9-10-23-27(17-22)35-15-13-28(23)42-29-11-8-21(16-25(29)34)38-32-30-26(12-14-36-32)37-18-24(31(30)39)20-6-4-3-5-7-20/h3-18,40H,19H2,1-2H3,(H,36,38)(H,37,39)
InChIKey
DGRCFAYRKDYEMX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MET kinase-IN-2
CAS: 2101241-90-9
CID: 134401435
Formula: C33H27FN4O4
MW: 562.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight562.6
XLogP36.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass562.20163352
Monoisotopic Mass562.20163352
Topological Polar Surface Area106 Ų
Heavy Atom Count42
Formal Charge0
Complexity958
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19215535-01Met-kinase-in-2
HY-131065-01MET kinase-IN-2
HY-146884MET kinase-IN-3
sc-204801Met Kinase Inhibitor
HY-18309-01MET kinase-IN-4
323675Met (HGF receptor, HGF-SF receptor, Met proto-oncogene tyrosine kinase, c-met, Kinase Met)
323676Met (HGF receptor, HGF-SF receptor, Met proto-oncogene tyrosine kinase, c-met, Kinase Met) discontinued
sc-364531Met Kinase Inhibitor III
abx332314MET Proto-Oncogene, Receptor Tyrosine Kinase (MET) Antibody
79559C-Met Kinase Assay Kit

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