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Lometrexol disodium

CAT: 0931-T63240-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63240-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
120408-07-3
Target
Others, Bcl-2 Family, Apoptosis, Caspase, Antifolate
Related Pathways
Apoptosis, Proteases/Proteasome, Others, Cell Cycle/Checkpoint
Bioactivity
Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer effects by inhibiting the de novo synthesis of purines, causing abnormal cell proliferation, apoptosis and cell cycle arrest.
Smiles
[Na+].[Na+].Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Cc2c(=O)[nH]1
Molecular Formula
C21H23N5Na2O6
Molecular Weight
487.424
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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