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Lometrexol

CAT: 0931-T15826-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15826-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
106400-81-1
Target
Antifolate, Apoptosis, Bcl-2 Family, Caspase, DHFR
Related Pathways
Metabolism, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Apoptosis, Proteases/Proteasome
Purity
0.9956
Bioactivity
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
Smiles
Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Molecular Formula
C21H25N5O6
Molecular Weight
443.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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