TM-1

• Target:

  Others|||Dehydrogenase

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  TM-1 is a potent pyruvate dehydrogenase kinase (PDHK) inhibitor that inhibits the activity of PDHK1 (IC50: 2.97 ?M) and PDHK2 (IC50: 5.2 ?M) . TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation and inhibits cancer cell proliferation.

• Smiles:

  COc1ccc (cc1OC) -c1c (C) c2ccc (OCCN3CCN (CCO) CC3) cc2oc1=O

• Molecular Formula:

  C26H32N2O6

• Molecular Weight:

  468.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  921099-13-0