PERK-IN-5

CAT: 0931-T63008-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T63008-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2616821-91-9
Target
PERK|||Others
Related Pathways
Apoptosis|||Others
Bioactivity
PERK-IN-5 is a highly selective, potent, orally active inhibitor of protein kinase R-like endoplasmic reticulum (ER) kinase (PERK), displaying inhibition with IC50 values of 2 nM for PERK and 9 nM for p-eIF2?. PERK-IN-5 significantly inhibited tumor growth in the 786-O renal cell carcinoma xenograft tumor model.
Smiles
CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)C
Molecular Formula
C25H26F2N4O3
Molecular Weight
468.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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