TGFβ-IN-2

CAT: 0931-T61586-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T61586-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2387678-02-4

Target

Others, TGF-beta/Smad

Related Pathways

Stem Cells, Others

Bioactivity

TGFβ-IN-2 (Compound 9d) effectively inhibits TGF-β-induced accumulation of total collagen in NRK-49F cells, with an IC50 value of 4.31 μM. It also suppresses the TGF-β-induced in vitro expression of COL1A1, α-SMA, and p-Smad3. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].

Smiles

O(C=1C=2C(OC(=O)C1)=CC=CC2)C3=CC=C(NC(CN4CCCCC4)=O)C=C3

Molecular Formula

C22H22N2O4

Molecular Weight

378.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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TGFβ-IN-2

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