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Triprolidine

CAT: 0931-T60514-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T60514-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
486-12-4
Target
Histamine Receptor, Others
Related Pathways
Neuroscience, Others, GPCR/G Protein, Immunology/Inflammation
Bioactivity
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3].
Smiles
CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=NC=CC=C1
Molecular Formula
C19H22N2
Molecular Weight
278.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Triprolidine

Triprolidine is an N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It is a member of pyridines, a N-alkylpyrrolidine and an olefinic compound. It is a conjugate base of a triprolidine(1+).

CAS Number486-12-4
PubChem CID5282443
IUPAC Name2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Molecular FormulaC19H22N2
Molecular Weight278.4
XLogP3.9
Topological Polar Surface Area16.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity335
SMILES
CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
InChI
InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
InChIKey
CBEQULMOCCWAQT-WOJGMQOQSA-N
Chemical Structure
2D Structure
2D structure of Triprolidine
CAS: 486-12-4
CID: 5282443
Formula: C19H22N2
MW: 278.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight278.4
XLogP33.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass278.178298710
Monoisotopic Mass278.178298710
Topological Polar Surface Area16.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity335
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-B1808-01Triprolidine
MBS3605311-01Triprolidine hydrochloride
RM-T281000-01Triprolidine Hcl
291808-01Triprolidine HCI
HY-B1808A-01Triprolidine (hydrochloride)
AR-T03078-01Triprolidine-d4
CS-O-44570Triprolidine N-Oxide
OR1076722Triprolidine aldehyde hydrochloride
sc-475344A(Z) -Triprolidine Hydrochloride
AR-T06033-01Triprolidine Impurity 1

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