Triprolidine (hydrochloride)

Triprolidine (hydrochloride)

• CAS Number: 550-70-9
• UNSPSC Description: Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis[1][2][3].
• Target Antigen: Histamine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/triprolidine-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl
• Molecular Weight: 314.85
• References & Citations: [1]Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. |[2]Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.|[3]Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7.
• Shipping Conditions: Room temperature
• Clinical Information: Launched