Ro5-3335

• Target:

  Others|||DNA/RNA Synthesis

• Related Pathways:

  DNA Damage/DNA Repair|||Others|||Cell Cycle/Checkpoint

• Purity:

  0.9995

• Bioactivity:

  Ro5-3335 (CBF?-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 ?M) . Ro5-3335 represses RUNX1/CBF?-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBF?. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

• Smiles:

  Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1

• Molecular Formula:

  C13H10ClN3O

• Molecular Weight:

  259.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  30195-30-3