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Ro5-3335

CAT: 0931-T4687-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4687-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
30195-30-3
Target
Others, DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint
Purity
0.9995
Bioactivity
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM) . Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
Smiles
Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1
Molecular Formula
C13H10ClN3O
Molecular Weight
259.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
C01564-5mgRo5-3335
217258CBF beta-Runx1 Inhibitor II (Ro5-3335)
GTR19260324-01Ro 5-3335
TBI5887-5MGRo 5-3335, RUNX1 inhibitor
256486Ro 5-3335 discontinued. See 217258
3335-100μgAnti-Estrogen Receptorα Antibody (3335) - 100 μg
E2261-01AEMP3 (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein) discontinued
MBS622887-01EMP3 (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein)
E2261-01A1EMP3 Blocking Peptide (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein) discontinued

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