Thio-ITP

CAT: 0931-T40359Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T40359Size:5 mg
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CAS Number
27652-34-2
Target
DNA/RNA Synthesis|||Others
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others
Bioactivity
Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 ?M for RNA polymerase I and 38.0 ?M for RNA polymerase II.
Smiles
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1[nH]cnc2=S
Molecular Formula
C10H15N4O13P3S
Molecular Weight
524.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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