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Oritinib mesylate

CAT: 0931-T39670Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T39670Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2180164-79-6
Target
EGFR, Others
Related Pathways
Others, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
Oritinib mesylate (SH-1028) is a highly selective, orally active, pyrimidine-based irreversible inhibitor of epidermal growth factor receptor (EGFR) with a low IC50 of 18 nM. It is effective against both EGFR-sensitive and resistant (T790M) mutations and suppresses the proliferation of tumor cells harboring EGFR mutations, irrespective of their sensitivity or resistance.
Smiles
CS(O)(=O)=O.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c2CCCCn2c2ccccc12
Molecular Formula
C32H41N7O5S
Molecular Weight
635.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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