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Calycosin

CAT: 0931-T3923-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T3923-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
20575-57-9
Target
Apoptosis|||Tyrosinase
Related Pathways
Proteases/Proteasome|||Apoptosis
Purity
>99.99%
Bioactivity
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ER?-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC (50) value of 38.4 microM.
Smiles
COc1ccc(cc1O)-c1coc2cc(O)ccc2c1=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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