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Calycosin (Standard)

CAT: 0804-HY-N0519R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0519R-01Size:5 mg
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Description
Calycosin (Standard) is the analytical standard of Calycosin. This product is intended for research and analytical applications. Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer[1][2].
CAS Number
20575-57-9
Product Name Alternative
Cyclosin (Standard)
UNSPSC
12352005
Target
Apoptosis; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/calycosin-standard.html
Smiles
O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=CC(O)=CC=C13
Molecular Formula
C16H12O5
Molecular Weight
284.26
References & Citations
[1]Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12.|[2]Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308 (2) :144-51.|[3]Guo C, et al. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012 Dec 18;144 (3) :768-74.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Calycosin

Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as an antioxidant and a metabolite. It is a member of 4'-methoxyisoflavones and a member of 7-hydroxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).

CAS Number20575-57-9
PubChem CID5280448
IUPAC Name7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one
Molecular FormulaC16H12O5
Molecular Weight284.26
XLogP2.4
Topological Polar Surface Area76
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity432
SMILES
COC1=C(C=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O
InChI
InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3
InChIKey
ZZAJQOPSWWVMBI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Calycosin
CAS: 20575-57-9
CID: 5280448
Formula: C16H12O5
MW: 284.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.26
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass284.06847348
Monoisotopic Mass284.06847348
Topological Polar Surface Area76 Ų
Heavy Atom Count21
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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