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GS-493

CAT: 0931-T39167Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T39167Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1710337-31-7
Target
Others|||Phosphatase
Related Pathways
Metabolism|||Others
Bioactivity
GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.
Smiles
OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)N(=O)=O)c2ccc(cc2)N(=O)=O)cc1|c:14|
Molecular Formula
C21H14N6O8S
Molecular Weight
510.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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