GS-493

• Target :

  Others|||Phosphatase

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.

• Smiles :

  OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)N(=O)=O)c2ccc(cc2)N(=O)=O)cc1|c:14|

• Molecular Formula :

  C21H14N6O8S

• Molecular Weight :

  510.44

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1710337-31-7