Resolvin D4

• Target:

  Others|||Antibacterial

• Related Pathways:

  Microbiology/Virology|||Others

• Bioactivity:

  Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosis of bacteria, opsonized zymosan A, and apoptotic neutrophils by human macrophages.[3] It also promotes the clearance of apoptotic neutrophils by human fibroblasts.[3]

• Smiles:

  CC\C=C/C[C@H](O)\C=C/C=C/C\C=C\C=C\C=C\C(O)[C@@H](O)CCC(O)=O

• Molecular Formula:

  C22H32O5

• Molecular Weight:

  376.493

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1025684-60-9