Resolvin E2

CAT: 0931-T35881-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0931-T35881-01Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
865532-70-3
Target
Lipoxygenase|||Others
Related Pathways
Metabolism|||Others
Bioactivity
Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in mice fed normal chow, as well as in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD), by dietary supplementation with EPA.4Plasma levels of RvE2 are increased by dietary supplementation with fish oil containing ?-3 polyunsaturated fatty acids (PUFAs) in patients with peripheral artery disease or chronic kidney disease.1,5,6
Smiles
C([C@@H](/C=C/C=C\C/C=C\C/C=C\C=C\[C@@H](CC)O)O)CCC(O)=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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