Necrostatin-5

• Target:

  Necroptosis|||RIP kinase

• Related Pathways:

  Apoptosis|||NF-?B

• Purity:

  0.994

• Bioactivity:

  Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-?, with an EC50 of 240 nM.

• Smiles:

  O=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3

• Molecular Formula:

  C19H17N3O2S2

• Molecular Weight:

  383.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  337349-54-9