MCTR1

CAT: 0931-T37505-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0931-T37505-01Size:10 µg
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CAS Number
1784701-61-6
Target
Leukotriene Receptor|||Others
Related Pathways
Others|||GPCR/G Protein
Bioactivity
Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM) . Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.
Smiles
[C@@H](CS[C@@H]([C@H](C/C=C\C/C=C\CC)O)/C=C/C=C/C=C\C/C=C\CCC(O)=O)(NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
Molecular Formula
C32H47N3O9S
Molecular Weight
649.8
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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