MCTR2

CAT: 0931-T37506-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0931-T37506-01Size:10 µg
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CAS Number
1784701-62-7
Target
Others
Related Pathways
Others
Bioactivity
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by ?-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM) . Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2? in the exudate.
Smiles
[C@H](SC[C@@H](C(NCC(O)=O)=O)N)([C@H](C/C=C\C/C=C\CC)O)/C=C/C=C/C=C\C/C=C\CCC(O)=O
Molecular Formula
C27H40N2O6S
Molecular Weight
520.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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