Z-LLE-AMC

CAT: 0931-T37417-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T37417-01Size:1 mg

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CAS Number

348086-66-8

Target

Proteasome

Related Pathways

Ubiquitination, Proteases/Proteasome

Bioactivity

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Smiles

CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1

Molecular Formula

C35H44N4O9

Molecular Weight

664.756

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Z-Leu-Leu-Glu-AMC

Z-Leu-Leu-Glu-AMC is a tripeptide that is L-leu-L-leu-L-Glu with a Cbz group at the N-terminal and a 7-amino-4-methylcoumarin group at the C-terminal. It is a fluorogenic substrate for measuring the peptidylglutamyl peptide-hydrolyzing activity of the 20S proteasome. It has a role as a fluorochrome. It is a member of coumarins and a tripeptide. It is functionally related to a Leu-Leu-Glu.

CAS Number	348086-66-8
PubChem CID	25108642
IUPAC Name	(4S)-4-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-5-[(4-methyl-2-oxochromen-7-yl)amino]-5-oxopentanoic acid
Molecular Formula	C35H44N4O9
Molecular Weight	664.7
XLogP	4.3
Topological Polar Surface Area	189
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	17
Heavy Atom Count	48
Formal Charge	0
Complexity	1180

SMILES

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC3=CC=CC=C3

InChI

InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1

InChIKey

FOYHOBVZPWIGJM-KCHLEUMXSA-N

Chemical Structure

2D Structure

CAS: 348086-66-8

CID: 25108642

Formula: C35H44N4O9

MW: 664.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	664.7
XLogP3	4.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	17
Exact Mass	664.31082899
Monoisotopic Mass	664.31082899
Topological Polar Surface Area	189 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	1180
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T76232-01	Z-DEVD-AMC
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T207360-01	Z-LRGG-AMC TFA
T74192-01	Z-Leu-Arg-AMC
T36334-01	Z-VAD-AMC (acetate)
T78625-01	Z-Ala-Arg-Arg-AMC
T37053-01	Z-(L-Arg)-AMC (hydrochloride)
T38984-01	Z-Ala-Ala-Asn-AMC

Alternative Products

Catalog	Name
GTR19030056-01	Z-LLE-AMC
13466-AAT	(Z-LLE) 2R110
4001519.1	Z-Arg-AMC
GWB-E9DD43	Z-FR-AMC
BML-P137-0050	Z-RR-AMC
BML-P142-0020	Z-GPR-AMC
MBS5818141	Z-DEVD-AMC
HY-P4427	Z-VAN-AMC
HY-P2176	Z-LRGG-AMC
HY-P4392	Z-VAD-AMC

Z-LLE-AMC

Chemical Information

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