NS 6740

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  High affinity ?7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human) . Inhibits ACh (IC50 = 2.7 nM) at ?7 nAChR. Reduces LPS-induced TNF-? release from microglia enriched cultures. Anti-inflammatory.

• Smiles:

  Cl.FC(F)(F)c1cccc(c1)-c1ccc(o1)C(=O)N1CCN2CCC1CC2|TLB:16:18:22.23:25.26|

• Molecular Formula:

  C19H20ClF3N2O2

• Molecular Weight:

  400.83

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  753499-14-8