6?-hydroxy Dexamethasone

• Target :

  Others|||Glucocorticoid Receptor

• Related Pathways :

  Others|||Endocrinology/Hormones

• Bioactivity :

  6?-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6?- and 6?-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

• Smiles :

  F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(C[C@@H](O)C=4[C@]2(C)C=CC(=O)C4)[H]

• Molecular Formula :

  C22H29FO6

• Molecular Weight :

  408.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  55879-47-5