6?-hydroxy Dexamethasone

• Target:

  Others|||Glucocorticoid Receptor

• Related Pathways:

  Others|||Endocrinology/Hormones

• Bioactivity:

  6?-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6?- and 6?-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

• Smiles:

  F[C@@]12[C@] ([C@]3 ([C@] (C) (C[C@@H]1O) [C@] (C (CO) =O) (O) [C@H] (C) C3) [H]) (C[C@@H] (O) C=4[C@]2 (C) C=CC (=O) C4) [H]

• Molecular Formula:

  C22H29FO6

• Molecular Weight:

  408.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  55879-47-5