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CAY10763

CAT: 0931-T36645-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T36645-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2364458-49-9
Target
Others
Related Pathways
Others
Bioactivity
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively) . It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively.
Smiles
COc1cc(NC(=O)[C@@H](Cc2ccccc2)NC2=CC(=NO)c3ccccc3C2=O)cc(OC)c1|w:20.21,t:18|
Molecular Formula
C27H25N3O5
Molecular Weight
471.513
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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463462CAY10763

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