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Endosidin-2

CAT: 0931-T37020-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T37020-06Size:100 mg
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CAS Number
1839524-44-5
Target
Others
Related Pathways
Others
Purity
0.9829
Bioactivity
Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1) .Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
Smiles
COC1=CC(\C=N\NC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O
Molecular Formula
C15H12FIN2O3
Molecular Weight
414.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Endosidin2

a conserved exocyst complex subunit EXO70 that inhibits exocytosis

CAS Number1839524-44-5
PubChem CID135504490
IUPAC Name3-fluoro-N-[(E)-(4-hydroxy-3-iodo-5-methoxyphenyl)methylideneamino]benzamide
Molecular FormulaC15H12FIN2O3
Molecular Weight414.17
XLogP3.2
Topological Polar Surface Area70.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity410
SMILES
COC1=C(C(=CC(=C1)/C=N/NC(=O)C2=CC(=CC=C2)F)I)O
InChI
InChI=1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
InChIKey
UIADDCURKKFTFW-QGMBQPNBSA-N
Chemical Structure
2D Structure
2D structure of Endosidin2
CAS: 1839524-44-5
CID: 135504490
Formula: C15H12FIN2O3
MW: 414.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight414.17
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass413.98767
Monoisotopic Mass413.98767
Topological Polar Surface Area70.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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