Endosidin-2

CAT: 0804-HY-120821-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120821-01Size:5 mg
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Description
Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation) . Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) [1][2].
CAS Number
[1839524-44-5]
Product Name Alternative
ES2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/endosidin-2.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CC(OC)=C(O)C(I)=C1)C2=CC=CC(F)=C2
Molecular Formula
C15H12FIN2O3
Molecular Weight
414.17
Precautions
H315, H319
References & Citations
[1]Zhang C, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016 Jan 5;113 (1) :E41-50.|[2]Lešková A, et al. Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1. PLoS One. 2020 Aug 13;15 (8) :e0237448.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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