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OH-Chol

CAT: 0931-T37018-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T37018-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
191173-82-7
Target
Others|||Liposome
Related Pathways
Others|||Metabolism
Bioactivity
OH-Chol is a cationic cholesterol derivative. OH-Chol, as a component of lipoplexes with [DOPE], has been used for siRNA delivery and gene silencing in MCF-7 cells and in mice via intravenous injection, resulting in lipoplex accumulation in the liver. Additionally, it has been employed in cationic nanoparticles with [Tween 80] to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with [Tween 80] and [folate-PEG2000-DSPE] in a KB mouse xenograft model for intratumoral gene delivery.
Smiles
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NCCNCCO)[C@H](C)CCCC(C)C|t:9|
Molecular Formula
C32H56N2O2
Molecular Weight
500.812
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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