OH-Chol

• Target:

  Others|||Liposome

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  OH-Chol is a cationic cholesterol derivative. OH-Chol, as a component of lipoplexes with [DOPE], has been used for siRNA delivery and gene silencing in MCF-7 cells and in mice via intravenous injection, resulting in lipoplex accumulation in the liver. Additionally, it has been employed in cationic nanoparticles with [Tween 80] to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with [Tween 80] and [folate-PEG2000-DSPE] in a KB mouse xenograft model for intratumoral gene delivery.

• Smiles:

  [H][C@@]1 (CC[C@@]2 ([H]) [C@]3 ([H]) CC=C4C[C@H] (CC[C@]4 (C) [C@@]3 ([H]) CC[C@]12C) C (=O) NCCNCCO) [C@H] (C) CCCC (C) C |t:9|

• Molecular Formula:

  C32H56N2O2

• Molecular Weight:

  500.812

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  191173-82-7