7?,27-dihydroxy Cholesterol

CAT: 0931-MF-0060706-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-MF-0060706-01Size:500 µg
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CAS Number
240129-43-5
Target
Others|||ROR
Related Pathways
Others|||Metabolism
Bioactivity
7?,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor ? (ROR?) and ROR?t. [1] It activates ROR?- or ROR?t-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7?,27-dihydroxy Cholesterol is selective for ROR? and ROR?t over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7?,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse ?? T cells stimulated with 12-myristate 13-acetate and ionomycin .
Smiles
C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Molecular Formula
C27H46O3
Molecular Weight
418.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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