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CMC2.24

CAT: 0931-T36492-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T36492-01Size:25 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1255639-43-0
Target
Apoptosis|||Ras|||MMP|||Others
Related Pathways
GPCR/G Protein|||MAPK|||Others|||Proteases/Proteasome|||Apoptosis
Bioactivity
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 ?M. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-?B/HIF-2? axis[1][2][3].
Smiles
Oc1ccc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(O)cc2)cc1
Molecular Formula
C26H21NO5
Molecular Weight
427.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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