CMC2.24

• Target :

  Apoptosis|||Ras|||MMP|||Others

• Related Pathways :

  GPCR/G Protein|||MAPK|||Others|||Proteases/Proteasome|||Apoptosis

• Bioactivity :

  CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 ?M. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-?B/HIF-2? axis[1][2][3].

• Smiles :

  Oc1ccc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(O)cc2)cc1

• Molecular Formula :

  C26H21NO5

• Molecular Weight :

  427.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1255639-43-0