8-iso Prostaglandin E2

CAT: 0931-T36160-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T36160-01Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

27415-25-4

Target

Others, Prostaglandin Receptor

Related Pathways

GPCR/G Protein, Immunology/Inflammation, Others

Bioactivity

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.

Smiles

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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8-iso Prostaglandin E2

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