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Coumarin-SAHA

CAT: 0931-T36105-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36105-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1260635-77-5
Target
Others, HDAC
Related Pathways
DNA Damage/DNA Repair, Others, Chromatin/Epigenetic
Bioactivity
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
Smiles
Cc1cc(=O)oc2cc(NC(=O)CCCCCCC(=O)NO)ccc12
Molecular Formula
C18H22N2O5
Molecular Weight
346.383
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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