Brevetoxin B

CAT: 0931-T36068Size: 100 µgDry Ice: NoHazardous: No
CAT#:0931-T36068Size:100 µg
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CAS Number
79580-28-2
Target
Others|||Sodium Channel
Related Pathways
Membrane transporter/Ion channel|||Others
Bioactivity
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Smiles
[H][C@]12C[C@@]3([H])O[C@H](CC(=C)C=O)C[C@H](O)[C@]3(C)O[C@]1([H])C[C@]1([H])O[C@]3([H])C[C@]4(C)O[C@]5(C)CC[C@]6([H])O[C@]7([H])C[C@]8(C)O[C@]9([H])C(C)=CC(=O)O[C@@]9([H])C[C@@]8([H])O[C@@]7([H])C[C@@H](C)[C@@]6([H])O[C@@]5([H])C[C@@]4([H])O[C@@]3(C)CC=C[C@@]1([H])O2|w:74.82,c:48|
Molecular Formula
C50H70O14
Molecular Weight
895.096
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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