SR 1903

CAT: 0931-MF-0037452-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0037452-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1414248-06-8
Target
ROR|||Liver X Receptor|||Others|||PPAR
Related Pathways
DNA Damage/DNA Repair|||Others|||Metabolism
Bioactivity
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor ? (ROR?) and liver X receptor (LXR) .1 It is an inverse agonist of ROR? (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor ? (PPAR?; IC50 = 209 nM) but does not activate it. SR 1903 (10 ?M) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1 in RAW 264.7 cells. SR 1903 (20 mg/kg twice per day) reduces severity score in a mouse model of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.
Smiles
CC1=C(C2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)C=CC(CN3CCN(CC=4C=CN=CC4)CC3)=C1
Molecular Formula
C27H27F6N3O
Molecular Weight
523.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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