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ATAG 2139

CAT: 0931-T35474Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T35474Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%) . Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below) . (MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in - see protocol for more information.)
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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