Tyrphostin 8

• Target:

  Phosphatase|||GTPase|||Ras|||EGFR

• Related Pathways:

  GPCR/G Protein|||MAPK|||JAK/STAT signaling|||Metabolism|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity:

  0.9986

• Bioactivity:

  Tyrphostin 8 (4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 ?M.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 ?M), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect.

• Smiles:

  OC1=CC=C (C=C (C#N) C#N) C=C1

• Molecular Formula:

  C10H6N2O

• Molecular Weight:

  170.17

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3785-90-8