AZD-1480

• Target :

  JAK

• Related Pathways :

  Stem Cells|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Angiogenesis

• Purity :

  0.9947

• Bioactivity :

  AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.

• Smiles :

  C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1

• Molecular Formula :

  C14H14ClFN8

• Molecular Weight :

  348.77

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  935666-88-9