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AZD-1480

CAT: 0931-T3069-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T3069-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
935666-88-9
Target
JAK
Related Pathways
Stem Cells, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis
Purity
0.9947
Bioactivity
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.
Smiles
C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1
Molecular Formula
C14H14ClFN8
Molecular Weight
348.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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