AZD-3409

CAT: 0931-MF-0063880-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0063880-01Size:25 mg
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CAS Number
345915-10-8
Target
Others
Related Pathways
Others
Bioactivity
AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. The mean IC (50) for cytotoxicity of AZD3409 was 510 in MEF cells, 10,600 in A549 cells and 6,170 in MCF7 cells, respectively. In these cells, the IC (50) for FTase activity of AZD3409 ranged from 3.0 to 14.2 nM and of lonafarnib from 0.26 to 31.3 nM. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. Both inhibition of farnesylation and geranylgeranylation could not be correlated to the antiproliferative activity of the drug. AZD3409 might be active in gefitinib-resistant breast carcinoma.
Smiles
C(N[C@H](C(OC(C)C)=O)CCSC)(=O)C1=C(CCC2=CC=C(F)C=C2)C=CC(NC[C@@H]3C[C@H](SC(=O)C=4C=CC=NC4)CN3)=C1
Molecular Formula
C34H41FN4O4S2
Molecular Weight
652.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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