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Avitinib

CAT: 0931-T3024-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T3024-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1557267-42-1
Target
BTK, Apoptosis, JAK, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells, Angiogenesis
Purity
>99.99%
Bioactivity
Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.
Smiles
CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1F
Molecular Formula
C26H26FN7O2
Molecular Weight
487.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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