APG-1387

CAT: 0931-T30095-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T30095-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1570231-89-8

Target

Others, Apoptosis, IAP

Related Pathways

Others, Apoptosis

Bioactivity

APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's CDDP and 5-FU enhance chemoresensitivity and promote cell apoptosis in vitro and in vivo.

Smiles

[H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)S(=O)(=O)c1cccc(c1)S(=O)(=O)N1CC[C@@]2([H])CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1

Molecular Formula

C60H72N10O10S2

Molecular Weight

1157.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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