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Recombinant Bovine Basic Fibroblast Growth Factor

CAT: 0355-AP60267Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60267Size:Inquire
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Background
Bovine bFGF, encoded by the FGF2 gene, is a member of the fibroblast growth factor (FGF) family. Fibroblast growth factor was found in pituitary extracts in 1973 and then tested in a bioassay that caused fibroblasts to proliferate. After further fractionating the extract using acidic and basic pH, twodifferent forms have isolated thatnamed "acidic fibroblast growth factor" (FGF-1) and "basic fibroblast growth factor" (FGF-2) . Bovine bFGF shares 95 % amino acidsequence identity with murine bFGF, and 97 % amino acidsequence identity with rat. Affinity between bFGF and its receptors can be increased by heparin or heparan sulfate proteoglycan. bFGF plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. It is also involved in a variety of biological processes, including embryonic development, morphogenesis, tissue repair, tumor growth and invasion. Additionally, bFGF is frequently used for a critical component of cell culture medium, e.g., human embryonic stem cell culture medium, serum-free culture systems.
Product Name Alternative
FGF-2, HBGF-2
Gene ID
281161
UniProt
P03969
Target
MPALPEDGGS GAFPPGHFKD PKRLYCKNGG FFLRIHPDGR VDGVREKSDP HIKLQLQAEE RGVVSIKGVC ANRYLAMKED GRLLASKCVT DECFFFERLE SNNYNTYRSR KYSSWYVALK RTGQYKLGPK TGPGQKAILF LPMSAKS
Purification
> 97 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rBobFGF as determined by LAL method.
Bioactivity
7
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 16.5 kDa, a single non-glycosylated polypeptide chain containing 147 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli

UniProtKB · P03969

Fibroblast growth factor 2

FGF2_BOVIN · Bos taurus

View on UniProt ↗
Primary accession
P03969
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGF2
Protein existence
1: Evidence at protein level
Organism
Bos taurus (Bovine)
Taxonomy ID
9913
Alternative names
FGF-2
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Biological process

AngiogenesisDifferentiation

Molecular function

Developmental proteinGrowth factorHeparin-bindingMitogen

Technical term

Direct protein sequencingReference proteome

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Cellular component

NucleusSecreted

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