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UR-7247

CAT: 0931-T29075-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T29075-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
177847-28-8
Target
RAAS
Related Pathways
Endocrinology/Hormones
Purity
1
Bioactivity
UR-7247 is a novel orally active angiotensin II subtype I (AT1) antagonist, demonstrating very long pharmacological effects. in vivo studies indicate no significant difference between 10 mg UR-7247 and 100 mg losartan four hours post-administration, while in vitro blockade with 100 mg losartan exceeds that observed with UR-7247, confirming UR-7247’s extended plasma half-life potentially due to high-affinity protein binding, highlighting its long-lasting, well-tolerated AT1 receptor antagonism in healthy subjects.
Smiles
O=C(O)C=1C(=NN(C1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCC)C(C)C
Molecular Formula
C24H26N6O2
Molecular Weight
430.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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