TG6-129

• Target:

  Prostaglandin Receptor

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation

• Purity:

  0.9955

• Bioactivity:

  TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1?, IL-6, IL-12, IL-23 and TNF-? induced by the EP2-selective agonist butaprost in P388D1 macrophages.

• Smiles:

  CCC1=NN=C(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)\C=C\C3=CC=C(F)C=C3)C=C2)S1

• Molecular Formula:

  C20H18FN5O3S3

• Molecular Weight:

  491.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1164464-14-5