TG6-129

CAT: 0931-T28958-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T28958-01Size:1 mg
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CAS Number
1164464-14-5
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein|||Immunology/Inflammation
Purity
0.9955
Bioactivity
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1?, IL-6, IL-12, IL-23 and TNF-? induced by the EP2-selective agonist butaprost in P388D1 macrophages.
Smiles
CCC1=NN=C(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)\C=C\C3=CC=C(F)C=C3)C=C2)S1
Molecular Formula
C20H18FN5O3S3
Molecular Weight
491.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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M27930-01TG6-129
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