TG6-129

• Target :

  Prostaglandin Receptor

• Related Pathways :

  GPCR/G Protein|||Immunology/Inflammation

• Purity :

  0.9955

• Bioactivity :

  TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1?, IL-6, IL-12, IL-23 and TNF-? induced by the EP2-selective agonist butaprost in P388D1 macrophages.

• Smiles :

  CCC1=NN=C(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)\C=C\C3=CC=C(F)C=C3)C=C2)S1

• Molecular Formula :

  C20H18FN5O3S3

• Molecular Weight :

  491.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1164464-14-5