Products for Research Use Only

ProTAME

CAT: 0931-T28455Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T28455Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1362911-19-0
Target
Others, APC/C
Related Pathways
Others, Cell Cycle/Checkpoint
Bioactivity
ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell lines, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.This compound is unstable in powder form and other related salt forms are recommended.
Smiles
COC(=O)[C@H](CCCN=C(NC(=O)OCOC(=O)Cc1ccccc1)NC(=O)OCOC(=O)Cc1ccccc1)NS(=O)(=O)c1ccc(C)cc1
Molecular Formula
C34H38N4O12S
Molecular Weight
726.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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