PF-06278121

• Target:

  Others|||Trk receptor

• Related Pathways:

  Others|||Tyrosine Kinase/Adaptors

• Bioactivity:

  PF-06278121 is a potent and selective Trk inhibitor. PF-06278121 shows Trk A/B IC50 = 4/94 nM (enzymatic assay), Trk A/B/C IC50 = 13/7/6 nM (PathHunter cell assay) .

• Smiles:

  C (=O) (C=1C=2C (N ([C@H] (CO) C) C1) =NC=NC2) C=3C=C (NC (CC4=CC=C (C (F) (F) F) C=C4) =O) C=NC3

• Molecular Formula:

  C24H20F3N5O3

• Molecular Weight:

  483.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1402438-37-2