OSI-296

CAT: 0931-T28271-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T28271-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1175296-94-2

Target

C-Met/HGFR, Others

Related Pathways

Tyrosine Kinase/Adaptors, Others

Bioactivity

OSI-296 is a potent and dual inhibitor of cMET and RON kinases (IC50 value are 42 nM and 200 nM for cMet and sfRon respectively) . OSI-206 shows in vivo efficacy and is well tolerated in tumor xenografts models upon oral dosing. OSI-296 also reduces tumour growth in the bone.

Smiles

O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=C3C(C(=CO3)C=4CCN(C(N)=O)CC4)=CN=C2N

Molecular Formula

C21H19Cl2FN4O3

Molecular Weight

465.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS5777963	OSI-296
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OSI-296

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