CM-414

CAT: 0931-T27051-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T27051-01Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1624792-70-6

Target

Others, PDE, HDAC

Related Pathways

Metabolism, Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer's Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively) . Chronic treatment of Tg2576 mice with CM-414 diminished brain Aβ and tau phosphorylation (pTau) levels, increased the inactive form of GSK3β, reverted the decrease in dendritic spine density on hippocampal neurons, and reversed their cognitive deficits, at least in part by inducing the expression of genes related to synaptic transmission.

Smiles

C(CC)C=1C2=C(C(=O)N=C(N2)C3=C(OCC)C=CC(C[C@H]4C[C@@H](C(NO)=O)C4)=C3)N(C)N1

Molecular Formula

C23H29N5O4

Molecular Weight

439.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-119316	CM-414
sc-503588	BIRH 414
HY-176935	BTP 414
sc-499429	RH 414
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TRC-B399702-100MG	BIRH 414-d5
GTR19224272-01	UK-414,495
GTR19276356-01	CRBN ligand-414
pro-2383	TARDBP (1-414)

CM-414

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