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CM-414

CAT: 0931-T27051-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T27051-01Size:100 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1624792-70-6
Target
Others|||PDE|||HDAC
Related Pathways
Metabolism|||Others|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer's Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively) . Chronic treatment of Tg2576 mice with CM-414 diminished brain A? and tau phosphorylation (pTau) levels, increased the inactive form of GSK3?, reverted the decrease in dendritic spine density on hippocampal neurons, and reversed their cognitive deficits, at least in part by inducing the expression of genes related to synaptic transmission.
Smiles
C(CC)C=1C2=C(C(=O)N=C(N2)C3=C(OCC)C=CC(C[C@H]4C[C@@H](C(NO)=O)C4)=C3)N(C)N1
Molecular Formula
C23H29N5O4
Molecular Weight
439.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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