BMS-814580

CAT: 0931-MF-0044911-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0044911-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1197420-11-3
Target
Melanin-concentrating Hormone Receptor (MCHR) |||GPCR
Related Pathways
Endocrinology/Hormones|||GPCR/G Protein
Bioactivity
BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively) . MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.
Smiles
O=C1C2=C(C=C(S2)C3=CC=C(Cl)C=C3)N=CN1C4=CC(OC)=C(OCC5(O)CC(F)(F)C5)C=C4
Molecular Formula
C24H19ClF2N2O4S
Molecular Weight
504.93
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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