BMS-814580

• Target:

  Melanin-concentrating Hormone Receptor (MCHR) |||GPCR

• Related Pathways:

  Endocrinology/Hormones|||GPCR/G Protein

• Bioactivity:

  BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively) . MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.

• Smiles:

  O=C1C2=C(C=C(S2)C3=CC=C(Cl)C=C3)N=CN1C4=CC(OC)=C(OCC5(O)CC(F)(F)C5)C=C4

• Molecular Formula:

  C24H19ClF2N2O4S

• Molecular Weight:

  504.93

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1197420-11-3