BMS-814580

• Target :

  Melanin-concentrating Hormone Receptor (MCHR) |||GPCR

• Related Pathways :

  Endocrinology/Hormones|||GPCR/G Protein

• Bioactivity :

  BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively) . MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.

• Smiles :

  O=C1C2=C(C=C(S2)C3=CC=C(Cl)C=C3)N=CN1C4=CC(OC)=C(OCC5(O)CC(F)(F)C5)C=C4

• Molecular Formula :

  C24H19ClF2N2O4S

• Molecular Weight :

  504.93

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1197420-11-3